| Dec 31,
2011 | Dec 31,
2012 | Dec 31,
2013 | Dec 31,
2014 | Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 |
|---|
| Research and development | 24 | 32 | 36 | 48 | 48 | 51 | 56 | 90 | 110 | 111 | 119 | 113 |
|---|
| General and Administrative Expense | 8 | 11 | 16 | 23 | 35 | 44 | 52 | 52 | 65 | 73 | 55 | 51 |
|---|
| Total costs and expenses | - | - | - | - | - | - | - | - | 175 | 184 | 174 | 163 |
|---|
| Loss from operations | -27 | -37 | -51 | -70 | -71 | -54 | -44 | -112 | -63 | -111 | -174 | -163 |
|---|
| Loss on early extinguishment of debt | - | - | - | - | -1 | -6 | - | -13 | - | -13 | - | - |
|---|
| Interest expense | 2 | 2 | 2 | 3 | 4 | 8 | 11 | 16 | 23 | 27 | 20 | 23 |
|---|
| Interest and other income | - | - | - | - | - | - | - | - | - | - | - | 4 |
|---|
| Loss from continuing operations before income tax benefit | - | - | - | - | - | - | - | -140 | -84 | -150 | -192 | -182 |
|---|
| Income tax benefit | - | - | - | - | - | - | - | -13 | - | -12 | - | - |
|---|
| Net loss from continuing operations | - | - | - | - | - | - | - | - | - | - | -191 | -182 |
|---|
| Net income from discontinued operations, net of tax | - | - | - | - | - | - | - | - | - | - | 386 | 229 |
|---|
| Net income (loss) | -29 | -38 | -40 | -74 | -75 | -67 | -53 | -127 | -84 | -138 | 194 | 47 |
|---|
| Basic net (loss) per share continuing operations | - | - | - | - | - | - | - | - | - | - | -3.07 | -2.9 |
|---|
| Basic net (loss) per share discontinued operations | - | - | - | - | - | - | - | - | - | - | 6.19 | 3.66 |
|---|
| Basic net income (loss) per share | - | - | - | - | - | - | - | - | - | - | 3.12 | 0.76 |
|---|
| Diluted net income per share continuing operations | - | - | - | - | - | - | - | - | - | - | -3.07 | -2.9 |
|---|
| Diluted net income per share discontinued operations | - | - | - | - | - | - | - | - | - | - | 6.19 | 3.66 |
|---|
| Diluted net income (loss) per share | - | - | - | - | - | - | - | - | - | - | 3.12 | 0.76 |
|---|