| Dec 31,
2011 | Dec 31,
2012 | Dec 31,
2013 | Dec 31,
2014 | Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 |
|---|
| Product sales | - | - | - | - | - | - | - | 21 | 20 | 18 | 24 | 20 |
|---|
| Royalty revenue | - | - | - | - | - | - | - | 42 | 41 | 31 | - | - |
|---|
| Non-cash royalty revenue related to the sales of future royalties | - | - | - | - | - | - | - | 33 | 36 | 49 | 78 | 70 |
|---|
| License, collaboration and other revenue | - | - | - | - | - | - | - | 1,097 | 17 | 56 | 0 | 2 |
|---|
| Total revenue | 71 | 81 | 149 | 201 | 231 | 165 | 308 | 1,193 | 115 | 153 | 102 | 92 |
|---|
| Cost of goods sold | - | - | - | - | - | - | - | 24 | 21 | 19 | 25 | 22 |
|---|
| Research and development | 127 | 149 | 190 | 148 | 183 | 204 | 268 | 400 | 435 | 409 | 400 | 218 |
|---|
| General and administrative | 47 | 42 | 41 | 41 | 43 | 44 | 52 | 81 | 99 | 105 | 123 | 92 |
|---|
| Impairment Of Assets And Other Costs For Terminated Program | - | - | - | - | - | - | - | - | - | 45 | - | 136 |
|---|
| Total operating costs and expenses | 195 | 222 | 269 | 217 | 260 | 278 | 367 | 505 | 555 | 578 | 548 | 468 |
|---|
| Loss from operations | -124 | -141 | -120 | -16 | -29 | -113 | -60 | 688 | -440 | -425 | -446 | -376 |
|---|
| Liabilities, Fair Value Adjustment | - | - | - | - | - | - | - | - | - | - | -8 | 33 |
|---|
| Non-cash interest expense on liabilities related to the sales of future royalties | - | - | - | 61 | 82 | 102 | 120 | 142 | 167 | 197 | 244 | 273 |
|---|
| Loss on revaluation of liability related to the sale of future royalties | - | - | - | - | - | - | - | - | - | - | -24 | - |
|---|
| Other Nonoperating Income (Expense) | -1 | 1 | 0 | 1 | 2 | 2 | 5 | 38 | 46 | 18 | 3 | 7 |
|---|
| Interest expense | 10 | 15 | 18 | 18 | 18 | 22 | 22 | 22 | 21 | 7 | - | - |
|---|
| Total non-operating income (expense), net | -9 | -30 | -40 | -38 | -51 | -40 | -36 | -5 | -0 | -19 | -77 | 11 |
|---|
| Loss before provision for income taxes | -133 | -171 | -160 | -54 | -81 | -153 | -96 | 683 | -440 | -444 | -523 | -365 |
|---|
| Provision for income taxes | 1 | 0 | 2 | -1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 3 |
|---|
| Net loss | -134 | -172 | -162 | -54 | -81 | -154 | -97 | 681 | -441 | -444 | -524 | -368 |
|---|
| Earnings Per Share, Basic | - | - | - | - | - | - | - | 4.02 | -2.52 | -2.49 | -2.86 | -1.97 |
|---|
| Earnings Per Share, Diluted | - | - | - | - | - | - | - | 3.78 | -2.52 | -2.49 | -2.86 | -1.97 |
|---|