| Jan 2, 2011 | Jan 1, 2012 | Dec 30, 2012 | Dec 29, 2013 | Dec 28, 2014 | Jan 3, 2016 | Jan 1, 2017 | Dec 31, 2017 | Dec 30, 2018 | Dec 29, 2019 | Jan 3, 2021 | Jan 2, 2022 | Jan 1, 2023 | Dec 31, 2023 | Dec 29, 2024 |
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| Net loss | 125 | 87 | 151 | 125 | 353 | 462 | 463 | 726 | 826 | 1,002 | 656 | 762 | -4,404 | -1,161 | -1,223 |
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| Depreciation | 34 | 56 | 48 | 51 | 62 | 73 | 90 | 110 | 140 | 151 | 156 | 176 | 215 | 235 | 224 |
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| Amortization of intangible assets | 8 | - | - | 47 | 51 | 54 | 51 | 46 | 39 | 37 | 31 | 75 | 179 | 197 | 130 |
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| Share-based compensation expense | 72 | 92 | 94 | 106 | 153 | 133 | 129 | 164 | 193 | 194 | 194 | 754 | 366 | 380 | 370 |
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| Deferred income taxes | - | - | - | - | - | -81 | -94 | -81 | 18 | -11 | -117 | 76 | 23 | 33 | 112 |
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| Net losses on strategic investments | - | - | - | - | - | - | - | - | - | - | - | 18 | -122 | -40 | -312 |
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| Change in fair value of contingent consideration liabilities | - | - | - | -19 | -5 | -6 | -1 | - | - | - | - | 4 | -205 | -24 | -315 |
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| (Gain) loss on Helix contingent value right | - | - | - | - | - | - | - | - | - | - | - | 30 | -7 | 10 | 15 |
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| Goodwill and Intangible Asset Impairment | - | - | - | - | - | - | - | - | - | - | - | - | - | 827 | 1,889 |
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| Property and equipment and right-of-use asset impairment | - | - | - | - | - | - | - | - | - | - | - | - | - | 100 | 46 |
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| Other | - | -9 | -8 | -5 | -9 | -10 | -15 | -1 | 17 | 1 | 33 | -29 | -17 | -10 | -14 |
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| Accounts receivable | 8 | 7 | 34 | 16 | 50 | 96 | -3 | 26 | 105 | 58 | -89 | 164 | 12 | 40 | 25 |
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| Inventory | 49 | -22 | 24 | -6 | 37 | 81 | 30 | 33 | 53 | -25 | 12 | 58 | 135 | 20 | -19 |
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| Prepaid expenses and other current assets | -3 | 2 | 3 | -2 | -7 | 11 | 1 | -8 | -5 | 14 | 20 | 64 | -16 | -11 | 14 |
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| Operating lease right-of-use assets and liabilities, net | - | - | - | - | - | - | - | - | - | 5 | 11 | 13 | 8 | 16 | 32 |
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| Other assets | - | - | - | - | - | 1 | 7 | 5 | 9 | 30 | 33 | 27 | -19 | -5 | 15 |
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| Accounts payable | - | - | - | - | - | 46 | -2 | 10 | 45 | -35 | 40 | 60 | -38 | -44 | -4 |
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| Accrued liabilities | 32 | 43 | 24 | 39 | 84 | 80 | -24 | 81 | 103 | -44 | -7 | 101 | 381 | 15 | -440 |
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| Other long-term liabilities | - | - | - | - | - | 5 | 16 | 160 | -4 | -33 | 27 | 13 | -19 | -1 | 28 |
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| Net cash provided by operating activities | 273 | 358 | 292 | 386 | 501 | 660 | 687 | 875 | 1,142 | 1,051 | 1,080 | 545 | 392 | 478 | 837 |
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| Net purchases of property and equipment | 50 | 78 | 69 | 79 | 106 | 143 | 260 | 310 | 296 | 209 | 189 | 208 | 286 | 195 | 128 |
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| Net purchases of strategic investments | - | - | - | - | - | - | - | - | - | - | - | - | 40 | 6 | 52 |
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| Cash paid for acquisitions and intangible assets, net of cash acquired | 98 | 58 | 83 | 524 | 3 | 37 | 18 | - | 100 | - | 98 | 2,444 | 85 | 29 | 81 |
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| Proceeds from Sale of Intangible Assets | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 83 |
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| Net cash used in investing activities | -285 | -401 | -150 | -70 | -407 | -106 | -515 | -214 | -1,813 | 745 | -554 | -1,069 | -591 | -231 | -178 |
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| Proceeds from debt, net of issuance costs | - | - | - | - | - | - | - | - | - | - | - | - | - | 1 | - |
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| Proceeds from Issuance of Long-Term Debt | - | - | - | - | - | - | 5 | 5 | 735 | - | - | 988 | 991 | - | 1,241 |
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| Payments on debt obligations | - | 350 | - | - | 1,245 | - | - | - | - | - | - | 517 | - | 1,235 | 750 |
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| Payments on contingent consideration liabilities | - | - | - | - | - | 3 | 29 | 3 | - | - | - | - | - | - | 1 |
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| Proceeds from issuance of common stock | 102 | 62 | 54 | 94 | 96 | 72 | 48 | 71 | 46 | 59 | 61 | 60 | 63 | 67 | 56 |
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| Taxes paid related to net share settlement of equity awards | - | - | - | - | 10 | 127 | 100 | 68 | 74 | 82 | 91 | 511 | 54 | 40 | 32 |
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| Common stock repurchases | 44 | 570 | 83 | 50 | 237 | 274 | 249 | 251 | 201 | 324 | 736 | - | - | - | 116 |
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| GRAIL cash deconsolidated as a result of spin-off | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 968 |
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| Net cash (used in) provided by financing activities | 116 | 97 | -11 | -39 | -167 | -419 | -205 | -176 | 594 | -897 | -766 | -51 | 1,000 | -1,210 | -570 |
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| Effect of exchange rate changes on cash and cash equivalents | - | - | - | - | - | - | - | - | - | -1 | 8 | -3 | -22 | - | -10 |
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| Net increase (decrease) in cash and cash equivalents | - | - | - | - | - | - | - | - | - | 898 | -232 | -578 | 779 | -963 | 79 |
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| Cash paid for interest | 2 | 2 | 3 | - | - | - | - | - | - | - | - | - | - | 73 | 83 |
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| Income Taxes Paid, Net | 32 | 10 | 74 | 50 | 18 | 17 | 60 | 149 | 99 | 164 | 119 | 233 | 122 | 65 | 105 |
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| Operating Lease, Payments | - | - | - | - | - | - | - | - | - | 84 | 86 | 96 | 112 | 123 | 132 |
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| Capital Expenditures Incurred but Not yet Paid | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4 |
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| Non cash Or Par tNon cash Spin off Net Assets Excluding Cash And Cash Equivalents | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,770 |
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