| Dec 31,
2011 | Dec 31,
2012 | Dec 31,
2013 | Dec 31,
2014 | Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 |
|---|
| Net loss | - | - | - | - | - | - | - | -25 | -21 | -1 | -36 | -35 |
|---|
| Gain on sale of equipment | - | - | - | - | - | - | - | - | - | - | 0 | - |
|---|
| Depreciation and accretion | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|---|
| Stock-based compensation | 7 | 4 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 3 | 2 |
|---|
| Inventory write-down | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | - | - |
|---|
| Amortization of debt issuance cost | - | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|---|
| Net accretion/amortization on investments | - | - | - | - | - | 0 | 0 | -0 | -0 | 0 | 0 | -0 |
|---|
| Changes in operating lease liabilities | - | - | - | - | - | - | - | - | 0 | -0 | -0 | -0 |
|---|
| Gain on sale of LACTEL product line | - | - | - | - | - | - | - | - | - | 13 | - | - |
|---|
| Accounts receivable | -0 | -1 | 0 | -0 | 0 | -1 | 1 | -1 | 1 | -0 | 5 | -3 |
|---|
| Inventories | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
|---|
| Prepaid expenses and other assets | -1 | 0 | -0 | -1 | 2 | -1 | 1 | 0 | -1 | 2 | -1 | -1 |
|---|
| Accounts payable | 0 | 1 | -1 | 0 | 0 | 1 | -1 | 0 | 1 | -0 | -0 | 2 |
|---|
| Accrued liabilities | - | 0 | - | - | 1 | 1 | 2 | 2 | 3 | 0 | 0 | 1 |
|---|
| Deferred revenue | - | - | - | - | - | - | - | -0 | 23 | -23 | 0 | -1 |
|---|
| Total adjustments | 1 | -30 | 6 | 8 | 2 | 7 | 2 | 6 | 32 | -38 | -1 | 9 |
|---|
| Net cash used in operating activities | -17 | -13 | -15 | - | - | - | - | -20 | 11 | -39 | -37 | -26 |
|---|
| Purchases of property and equipment | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|---|
| Purchases of available-for-sale securities | - | - | - | - | - | - | - | 10 | 32 | 45 | 52 | - |
|---|
| Proceeds from maturities of available-for-sale securities | 47 | 29 | 22 | 16 | 41 | 31 | 21 | 14 | 5 | 55 | 49 | 20 |
|---|
| Proceeds from sales of available-for-sale securities | - | - | - | - | - | - | - | - | - | - | 4 | - |
|---|
| Proceeds From Sale Of Product Line | - | - | - | - | - | - | - | - | - | - | 15 | - |
|---|
| Net cash provided by investing activities | 15 | 4 | 1 | - | - | - | - | 5 | -27 | 9 | 15 | 20 |
|---|
| Payments on equipment financing obligations | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
|---|
| Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised | - | - | - | 0 | 1 | 0 | 1 | 2 | 2 | 3 | 4 | 0 |
|---|
| Proceeds from Issuance of Common Stock | 1 | 0 | 0 | 5 | 14 | 24 | 12 | 17 | 18 | 12 | 48 | 0 |
|---|
| Term loan amendment cost | - | - | - | - | 0 | 0 | - | 1 | 1 | - | 1 | - |
|---|
| Net cash provided by financing activities | 1 | 12 | 11 | - | - | - | - | 17 | 20 | 16 | 51 | 0 |
|---|
| Net (decrease) increase in cash and cash equivalents | - | - | - | - | - | - | - | 2 | 3 | -14 | 29 | -6 |
|---|
| Cash paid for interest | - | - | - | - | - | - | - | 2 | 2 | 2 | 2 | 2 |
|---|
| Cash held in escrow | - | - | - | - | - | - | - | - | - | 15 | - | - |
|---|
| Stock Issued | - | - | - | - | - | - | 2 | 2 | 1 | - | - | - |
|---|
| Right-of-Use Asset Obtained in Exchange for Operating Lease Liability | - | - | - | - | - | - | - | - | 7 | - | - | - |
|---|