| Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 | Dec 31,
2023 | Dec 31,
2024 |
|---|
| Product Sales | 20,152 | 21,049 | 23,565 | 25,890 | 36,541 | 42,998 | 43,789 | 50,938 |
|---|
| Alliance Revenue | - | - | - | - | - | - | 1,428 | 2,212 |
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| Collaboration Revenue | - | - | 819 | 727 | 876 | 1,353 | 594 | 923 |
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| Total Revenue | 22,465 | 22,090 | 24,384 | 26,617 | 37,417 | 44,351 | 45,811 | 54,073 |
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| Cost of sales | 4,318 | 4,936 | 4,921 | 5,299 | 12,437 | 12,391 | 8,268 | 10,207 |
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| Gross profit | 18,147 | 17,154 | 19,463 | 21,318 | 24,980 | 31,960 | 37,543 | 43,866 |
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| Distribution expense | 310 | 331 | 339 | 399 | 446 | 536 | 539 | 555 |
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| Research and development expense | 5,757 | 5,932 | 6,059 | 5,991 | 9,736 | 9,762 | 10,935 | 13,583 |
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| Selling, general and administrative expense | 10,233 | 10,031 | 11,682 | 11,294 | 15,234 | 18,419 | 19,216 | 19,977 |
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| Other operating income (expense) | 1,830 | 2,527 | 1,541 | 1,528 | 1,492 | 514 | 1,340 | 252 |
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| Operating profit | 3,677 | 3,387 | 2,924 | 5,162 | 1,056 | 3,757 | 8,193 | 10,003 |
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| Finance income | 113 | 138 | 172 | 87 | 43 | 95 | 344 | 458 |
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| Finance expense | 1,508 | 1,419 | 1,432 | 1,306 | 1,300 | 1,346 | 1,626 | 1,742 |
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| Share of after tax losses in associates and joint ventures | -55 | -113 | -116 | -27 | -64 | -5 | -12 | -28 |
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| Profit before tax | 2,227 | 1,993 | 1,548 | 3,916 | -265 | 2,501 | 6,899 | 8,691 |
|---|
| Taxation | -641 | -57 | 321 | 772 | -380 | -792 | 938 | 1,650 |
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| Profit for the period | 2,868 | 2,050 | 1,227 | 3,144 | 115 | 3,293 | 5,961 | 7,041 |
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| Remeasurement of the defined benefit pension liability | -242 | -46 | -364 | -168 | 626 | 1,118 | -406 | 80 |
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| Other comprehensive income, before tax, gains (losses) from investments in equity instruments | - | -171 | -28 | 938 | -187 | -88 | 278 | 139 |
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| Fair value movements related to own credit risk on bonds designated as fair value through profit or loss | -9 | 8 | -5 | -1 | - | 2 | -6 | 12 |
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| Tax on items that will not be reclassified to profit and loss | -16 | -56 | -21 | 81 | -105 | 216 | -101 | 43 |
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| Total other comprehensive income that will not be reclassified to profit and loss, net of tax | -235 | -153 | -376 | 688 | 544 | 816 | -33 | 188 |
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| Foreign exchange arising on consolidation | - | - | - | - | - | -1,446 | 608 | -957 |
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| Foreign exchange arising on designated liabilities in net investment hedges | - | - | - | - | - | - | - | -122 |
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| Fair value movements on cash flow hedges | 311 | -37 | -101 | 180 | -167 | -97 | 266 | -129 |
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| Fair value movements on cash flow hedges transferred to profit and loss | 315 | -111 | -52 | 254 | -208 | -73 | 145 | -177 |
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| Fair value movements on derivatives designated in net investment hedges | - | - | - | - | 34 | -8 | 44 | 39 |
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| Costs of hedging | - | - | - | - | - | -7 | -19 | -21 |
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| Tax on items that may be reclassified subsequently to profit and loss | 33 | -51 | -38 | 39 | -46 | -73 | 12 | -25 |
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| Other comprehensive (loss)/income that may be reclassified to profit and loss, net of tax | 874 | -906 | -235 | 920 | -689 | -1,694 | 766 | -988 |
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| Other comprehensive (expense)/income for the period, net of tax | 639 | -1,059 | -611 | 1,608 | -145 | -878 | 733 | -800 |
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| Total comprehensive income for the period | 3,507 | 991 | 616 | 4,752 | -30 | 2,415 | 6,694 | 6,241 |
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| Owners of the Parent | 3,001 | 2,155 | 1,335 | 3,196 | 112 | 3,288 | 5,955 | 7,035 |
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| Non-controlling interests | -133 | -105 | -108 | -52 | 3 | 5 | 6 | 6 |
|---|
| Owners of the Parent | 3,640 | 1,097 | 723 | 4,804 | -33 | 2,413 | 6,688 | 6,236 |
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| Non-controlling interests | -133 | -106 | -107 | -52 | 3 | 2 | 6 | 5 |
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| Total comprehensive income for the period | 3,507 | 991 | 616 | 4,752 | -30 | 2,415 | 6,694 | 6,241 |
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| Basic earnings (loss) per share | 2.37 | 1.7 | 1.03 | 2.44 | 0.08 | 2.12 | 3.84 | 4.54 |
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| Diluted earnings (loss) per share | 2.37 | 1.7 | 1.03 | 2.44 | 0.08 | 2.11 | 3.81 | 4.5 |
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