| Dec 31,
2011 | Dec 31,
2012 | Dec 31,
2013 | Dec 31,
2014 | Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 |
|---|
| Net (loss) income | - | - | - | - | - | - | - | -116 | -23 | -18 | 8 | -106 |
|---|
| Depreciation and amortization | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 1 |
|---|
| Amortization of investments | - | - | - | - | - | - | - | - | - | -2 | -2 | -0 |
|---|
| Stock-based compensation | 9 | 18 | - | - | 14 | 14 | 14 | 19 | 31 | 46 | 37 | 26 |
|---|
| Amortization of Debt Issuance Costs and Discounts | - | 13 | 18 | 6 | 8 | 8 | 2 | 2 | 2 | 1 | - | - |
|---|
| Amortization of intangible asset | - | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 3 |
|---|
| Accounts receivable, net | - | - | 4 | 4 | 6 | 6 | 25 | 21 | 50 | 38 | 9 | -33 |
|---|
| Inventory | - | 21 | 5 | -13 | 5 | 2 | 10 | 28 | 19 | 112 | 167 | 36 |
|---|
| Prepaid and other current assets | - | - | - | - | 1 | 4 | -6 | -1 | 10 | 18 | -9 | -3 |
|---|
| Other long-term assets | 1 | 1 | -1 | -4 | -0 | 1 | -1 | - | 1 | -1 | 0 | 0 |
|---|
| Interest receivable | - | - | - | - | - | - | - | - | - | 1 | -1 | -0 |
|---|
| Accrued interest payable | - | 3 | 10 | 2 | -1 | -6 | -6 | -0 | -0 | -0 | - | - |
|---|
| Deferred revenue | - | - | - | - | - | - | - | 2 | 0 | -2 | -2 | -1 |
|---|
| Accounts payable, accrued expenses and other current liabilities | 6 | 26 | -7 | 9 | 10 | 9 | 40 | 38 | 66 | 115 | 52 | -103 |
|---|
| Other long-term liabilities | - | - | - | - | -0 | 0 | 0 | 9 | -6 | 3 | 1 | 1 |
|---|
| Net cash used in operating activities | -39 | -122 | -190 | - | - | - | - | -95 | -9 | -22 | -67 | -180 |
|---|
| Sale and maturities of securities | - | - | - | - | - | - | - | - | - | 302 | 394 | 258 |
|---|
| Purchases of securities | - | - | - | - | - | - | - | - | - | 679 | 290 | 82 |
|---|
| Investment in website development costs | - | 12 | - | - | - | - | - | - | - | - | - | 1 |
|---|
| Disposal (Purchase) of Furniture, Fixtures and Equipment | - | - | - | - | - | - | - | - | - | - | 0 | - |
|---|
| Net cash provided by (used in) investing activities | -2 | -14 | -0 | - | - | - | - | -0 | -2 | -377 | 104 | 175 |
|---|
| Proceeds from Issuance of Common Stock | 99 | - | 121 | - | - | 65 | - | 265 | 440 | - | - | - |
|---|
| Proceeds from issuance of common stock under employee stock purchase plan | - | - | - | - | - | - | - | 1 | 2 | 2 | 2 | 1 |
|---|
| Proceeds from Stock Options Exercised | 5 | 8 | 1 | 0 | 0 | 0 | 1 | 26 | 25 | 5 | 3 | 0 |
|---|
| Payment of transaction costs for conversion of preferred stock | - | - | - | - | - | - | - | 0 | - | 1 | - | - |
|---|
| Payment on debt from royalty-bearing instrument | - | - | - | - | - | - | 3 | 15 | 32 | 50 | - | - |
|---|
| Taxes related to stock-based awards | - | - | - | - | - | 1 | 3 | 6 | 25 | 15 | 10 | 1 |
|---|
| Net cash used in financing activities | 127 | 280 | 122 | - | - | - | - | 271 | 410 | -59 | -5 | -0 |
|---|
| NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | - | - | - | - | - | - | - | 176 | 398 | -458 | 32 | -5 |
|---|
| Interest | - | - | - | - | - | - | - | 22 | 5 | 2 | - | - |
|---|
| Income taxes | - | - | - | - | - | - | - | - | - | - | 4 | -2 |
|---|
| Laxdale milestone | - | - | - | - | - | - | - | - | 8 | - | 12 | - |
|---|
| Shares Issued In Settlement Of Milestone Payment | - | - | - | - | - | - | - | - | - | - | - | 8 |
|---|
| Initial recognition of operating lease right-of-use asset | - | - | - | - | - | - | - | - | 9 | - | - | 2 |
|---|
| Conversion of Stock, Amount Converted | - | - | - | - | 5 | - | - | 3 | - | 18 | - | - |
|---|