ALNYLAM PHARMACEUTICALS, INC.ALNY
| Dec 31, 2010 | Dec 31, 2011 | Dec 31, 2012 | Dec 31, 2013 | Dec 31, 2014 | Dec 31, 2015 | Dec 31, 2016 | Dec 31, 2017 | Dec 31, 2018 | Dec 31, 2019 | Dec 31, 2020 | Dec 31, 2021 | Dec 31, 2022 | Dec 31, 2023 | Dec 31, 2024 |
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| Net loss | -44 | -58 | -106 | -89 | -360 | -290 | -410 | -491 | -761 | -886 | -858 | -853 | -1,131 | -440 | -278 |
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| Depreciation and amortization | - | - | - | - | - | - | - | - | 6 | 17 | 35 | 48 | 44 | 54 | 57 |
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| Non-Cash Interest Expense On Sale Of Future Royalties | - | - | - | - | - | - | - | - | - | - | 84 | 117 | 104 | 107 | 127 |
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| Stock-based compensation | 19 | 17 | 12 | 21 | 33 | 46 | 76 | 93 | 158 | 175 | 140 | 166 | 231 | 222 | 272 |
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| Realized and unrealized losses on marketable equity securities | - | - | - | - | - | - | - | - | 4 | 11 | 54 | 56 | -33 | -17 | -3 |
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| Loss on extinguishment of debt | - | - | - | - | - | - | - | - | - | - | - | - | -77 | - | - |
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| Change in fair value of development derivative liability | - | - | - | - | - | - | - | - | - | 9 | - | - | -95 | -91 | -171 |
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| Deferred income taxes | - | - | - | - | - | - | - | - | - | -2 | -3 | -3 | -1 | -1 | -107 |
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| Other | - | - | - | - | - | - | - | 1 | - | -3 | 11 | 58 | 0 | 0 | -39 |
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| Accounts receivable, net | - | - | - | - | - | - | - | - | -15 | 24 | 56 | 102 | 46 | 88 | 87 |
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| Inventory | - | - | - | - | - | - | - | - | 23 | 32 | 35 | 26 | 34 | -18 | -14 |
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| Prepaid expenses and other assets | 3 | -3 | -2 | 1 | 6 | 7 | 5 | 21 | 35 | 22 | -15 | 32 | 39 | 9 | -3 |
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| Accounts payable, accrued expenses and other liabilities | - | - | - | - | - | - | - | - | - | 92 | 144 | 88 | 192 | 81 | 91 |
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| Deferred revenue | - | - | - | - | - | - | - | - | -13 | 392 | -44 | -50 | -66 | 55 | -235 |
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| Net cash (used in) provided by operating activities | -84 | -87 | -116 | -69 | - | - | - | - | -563 | -278 | -615 | -642 | -541 | 104 | -8 |
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| Purchases of property, plant and equipment | 5 | 1 | 8 | 4 | 9 | 13 | 65 | 104 | 127 | 140 | 70 | 76 | 72 | 62 | 34 |
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| Purchases of marketable securities | - | - | - | - | 978 | 1,034 | 759 | 903 | 1,104 | 2,076 | 2,026 | 1,656 | 1,977 | 1,824 | 1,635 |
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| Sales and maturities of marketable securities | - | - | - | - | - | - | - | - | 1,519 | 1,775 | 1,692 | 1,464 | 2,232 | 1,554 | 1,572 |
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| Proceeds from Sale of Restricted Investments | - | - | - | - | - | - | - | 120 | - | 30 | - | 42 | 90 | 58 | 58 |
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| Purchases of restricted investments | - | - | - | - | - | - | - | - | 15 | - | 26 | 42 | 98 | 58 | 77 |
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| Other investing activities | - | - | - | - | - | - | - | - | - | 7 | 5 | 4 | 5 | 4 | 0 |
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| Net cash (used in) provided by investing activities | 18 | 82 | 3 | -131 | - | - | - | - | 273 | -418 | -436 | -273 | 169 | -336 | -117 |
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| Proceeds from exercise of stock options and other types of equity, net | 3 | 1 | 7 | 29 | 29 | 31 | 14 | 84 | 69 | 71 | 200 | 246 | 259 | 147 | 303 |
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| Proceeds from Convertible Debt | - | - | - | - | - | - | - | - | - | - | - | - | 1,016 | - | - |
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| Purchases of capped calls related to convertible debt | - | - | - | - | - | - | - | - | - | - | - | - | 119 | - | - |
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| (Repayment of) proceeds from development derivative liability, net | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 9 |
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| Net cash provided by financing activities | 4 | 1 | 93 | 201 | - | - | - | - | 65 | 823 | 995 | 1,247 | 426 | 172 | 294 |
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| Effect of exchange rate changes on cash, cash equivalents and restricted cash | - | - | - | - | - | - | - | - | - | -0 | 5 | -9 | -7 | 6 | -15 |
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| Net increase (decrease) in cash, cash equivalents and restricted cash | - | - | - | - | - | - | - | - | -224 | 127 | -51 | 323 | 46 | -54 | 154 |
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| Cash paid for interest | - | - | - | - | - | - | - | - | 1 | 0 | - | 25 | 45 | 32 | 68 |
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| Income Taxes Paid, Net | 6 | 11 | -0 | -0 | 1 | -0 | 0 | - | - | - | - | - | - | - | 14 |
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| Right-of-Use Asset Obtained in Exchange for Operating Lease Liability | - | - | - | - | - | - | - | - | - | - | 34 | 8 | 1 | - | 9 |
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| Capital Expenditures Incurred but Not yet Paid | - | - | 1 | 0 | 2 | 1 | 33 | 8 | 33 | 15 | 15 | 14 | 5 | 4 | 2 |
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