Ultragenyx Pharmaceutical Inc.RARE
| Dec 31, 2014 | Dec 31, 2015 | Dec 31, 2016 | Dec 31, 2017 | Dec 31, 2018 | Dec 31, 2019 | Dec 31, 2020 | Dec 31, 2021 | Dec 31, 2022 | Dec 31, 2023 | Dec 31, 2024 |
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| Net loss | -60 | -146 | -246 | -302 | -198 | -403 | -187 | -454 | -707 | -607 | -569 |
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| Stock-based compensation | - | - | - | - | - | - | 86 | 105 | 130 | 135 | 158 |
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| Amortization of premium (discount) on marketable debt securities, net | -4 | -6 | -5 | -2 | 3 | 6 | -1 | -7 | -3 | 13 | 13 |
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| Depreciation and amortization | 1 | 1 | 3 | 6 | 20 | 9 | 12 | 13 | 18 | 26 | 36 |
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| Change in fair value of equity investments | - | - | - | - | - | 13 | 170 | -42 | -19 | 0 | -1 |
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| Non-cash collaboration royalty revenue | - | - | - | - | - | - | 13 | 18 | 22 | 69 | 101 |
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| Non-cash interest expense on liabilities for sales of future royalties | - | - | - | - | - | 1 | 33 | 29 | 43 | 66 | 63 |
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| Other | - | - | - | - | 0 | -1 | -1 | -0 | 0 | -2 | 3 |
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| Accounts receivable | - | - | - | - | 8 | 20 | -10 | 5 | 12 | 23 | 34 |
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| Inventory | - | - | - | - | 5 | 4 | 1 | 3 | 10 | 7 | 11 |
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| Prepaid expenses and other assets | - | - | - | - | - | - | - | - | - | - | -12 |
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| Other assets | - | - | - | - | - | - | - | - | - | -15 | - |
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| Accounts payable, accrued, and other liabilities | - | - | - | - | - | 13 | 27 | 32 | 87 | 2 | 47 |
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| Deferred tax liabilities | - | - | - | - | - | 2 | - | - | -2 | -2 | - |
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| Net cash used in operating activities | - | - | - | - | -291 | -345 | -132 | -339 | -380 | -475 | -414 |
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| Purchase of property, plant, and equipment | 2 | 5 | 10 | 3 | 4 | 25 | 44 | 73 | 116 | 44 | 7 |
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| Acquisition, net of cash acquired | - | - | - | 143 | - | - | - | - | 75 | - | - |
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| Purchase of marketable debt securities | - | - | - | - | - | - | 813 | 1,012 | 615 | 526 | 409 |
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| Proceeds from sale of marketable debt securities | - | - | - | - | - | - | 51 | 93 | 84 | 51 | 3 |
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| Proceeds From Sale Of Equity Investment | - | - | - | - | - | - | 80 | 80 | 10 | - | - |
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| Proceeds from maturities of marketable debt securities | 83 | 249 | 403 | 274 | 303 | 676 | 590 | 718 | 451 | 696 | 410 |
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| Payment for intangible asset | - | - | - | - | - | - | - | - | 30 | 3 | 13 |
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| Other | - | - | - | - | - | - | 6 | 1 | 1 | 5 | 2 |
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| Net cash (used in) provided by investing activities | - | - | - | - | -33 | -13 | -179 | -195 | -292 | 168 | -18 |
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| Proceeds from the sale of future royalties, net | - | - | - | - | - | 314 | - | - | 491 | - | - |
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| Proceeds from the issuance of common stock and pre-funded warrants in connection with underwritten public offerings, net of issuance costs | - | - | - | - | - | - | - | - | - | 326 | 381 |
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| Proceeds from the issuance of common stock in connection with at-the-market offering, net of issuances costs | - | - | - | - | - | - | - | - | - | 53 | - |
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| Proceeds from the issuance of common stock from exercise of equity plan awards, net | - | - | 8 | 9 | 28 | 10 | 89 | 40 | 11 | 8 | 11 |
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| Proceeds from Noncontrolling Interests | - | - | - | - | - | - | - | - | - | - | 7 |
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| Other | - | - | - | - | - | - | -0 | -0 | -1 | -0 | - |
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| Net cash provided by financing activities | - | - | - | - | 337 | 679 | 600 | 119 | 501 | 388 | 399 |
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| Effect of exchange rate changes on cash | - | - | - | - | -0 | -0 | 1 | -1 | -1 | 0 | -3 |
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| Net (decrease) increase in cash, cash equivalents, and restricted cash | - | - | - | - | 12 | 321 | 290 | -417 | -172 | 82 | -35 |
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| Acquired lease liabilities arising from obtaining right-of-use assets and property, plant, and equipment | - | - | - | - | - | - | - | - | - | 22 | 10 |
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| Capital Expenditures Incurred but Not yet Paid | - | 1 | 0 | 0 | 1 | 10 | 9 | 19 | 18 | 2 | 1 |
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| Non-cash interest expense on liability related to the sale of future royalties capitalized into ending property, plant and equipment | - | - | - | - | - | - | - | 5 | 11 | 9 | - |
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