| Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 | Dec 31,
2023 | Dec 31,
2024 |
|---|
| License | - | - | - | 22 | 177 | 14 | 116 | 23 | 10 | 1 |
|---|
| Development and Other Revenue | - | - | - | 126 | 114 | 81 | 70 | 24 | 18 | 2 |
|---|
| Product | - | - | - | 65 | -35 | 72 | 63 | 83 | 101 | - |
|---|
| Drug Product Revenue | - | - | - | - | - | 9 | 1 | 11 | 19 | 28 |
|---|
| Total revenue | - | - | - | 213 | 257 | 176 | 235 | 141 | 148 | 30 |
|---|
| Cost of Revenue | - | - | - | - | - | - | 13 | 20 | 19 | 16 |
|---|
| Research and development | 214 | 187 | 197 | 236 | 209 | 253 | 387 | 297 | 283 | 96 |
|---|
| Selling, general and administrative | - | - | - | - | 135 | 106 | 124 | 125 | 115 | 49 |
|---|
| Restructuring charge | - | - | - | - | - | - | - | - | 13 | 20 |
|---|
| Total operating costs and expenses | - | - | - | - | - | - | 524 | 442 | 430 | 180 |
|---|
| Loss from operations | -78 | -54 | -123 | -87 | -89 | -192 | -289 | -301 | -282 | -150 |
|---|
| Interest expense | 11 | 11 | 10 | 11 | 3 | 2 | 1 | 1 | 16 | 8 |
|---|
| Nonoperating Income (Expense) | - | - | - | - | - | - | -1 | 8 | 10 | 5 |
|---|
| Total interest and other, net | -8 | -8 | -3 | 1 | 13 | 3 | -2 | 6 | -5 | -3 |
|---|
| Loss from continuing operations before income taxes | - | - | - | - | - | - | -291 | -295 | -287 | -153 |
|---|
| Benefit from income taxes | 0 | -0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -0 |
|---|
| Loss from continuing operations | - | - | - | - | - | - | - | - | - | -153 |
|---|
| Income from discontinued operations, net of tax | - | - | - | - | - | - | - | - | - | 106 |
|---|
| Net loss | -86 | -62 | -126 | -86 | -77 | -189 | -290 | -294 | -284 | -48 |
|---|
| Loss from continuing operations per share - basic | - | - | - | - | - | - | - | - | - | -1.53 |
|---|
| Loss from continuing operations per share - diluted | - | - | - | - | - | - | - | - | - | -1.53 |
|---|
| Income from discontinued operations per share - basic | - | - | - | - | - | - | - | - | - | 1.05 |
|---|
| Income from discontinued operations per share - diluted | - | - | - | - | - | - | - | - | - | 1.05 |
|---|
| Net loss per share - basic | - | - | - | - | - | - | - | -3.14 | -2.92 | -0.48 |
|---|
| Net loss per share - diluted | - | - | - | - | - | - | - | -3.14 | -2.92 | -0.48 |
|---|