| Dec 31,
2011 | Dec 31,
2012 | Dec 31,
2013 | Dec 31,
2014 | Dec 31,
2015 | Dec 31,
2016 | Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 | Dec 31,
2023 | Dec 31,
2024 |
|---|
| Net loss | -60 | -41 | -56 | -79 | -118 | -176 | -193 | -324 | -254 | -294 | -435 | -482 | -750 | -914 |
|---|
| Depreciation | - | - | - | - | - | - | - | 4 | 5 | 9 | 9 | 5 | 6 | 6 |
|---|
| Amortization of intangible assets | - | - | - | - | - | - | - | 1 | 5 | 5 | 5 | 5 | 5 | 5 |
|---|
| Stock-based compensation expense | 2 | 3 | 9 | 11 | 16 | 18 | 18 | 26 | 27 | 36 | 46 | 58 | 75 | 97 |
|---|
| Amortization of debt issuance costs | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 7 |
|---|
| Paid-in-Kind Interest | - | - | - | - | - | - | - | - | - | - | - | 4 | 23 | 19 |
|---|
| Other Noncash Expense | - | - | - | - | - | - | - | - | - | - | - | 4 | 19 | 20 |
|---|
| Accretion of discount on marketable securities, net | - | - | - | - | - | - | - | - | - | - | - | - | - | 19 |
|---|
| Finance lease amortization expense | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 2 | 3 | 3 |
|---|
| Noncash Operating Lease Expense | - | - | - | - | - | - | - | - | 10 | 6 | 13 | 12 | 9 | 4 |
|---|
| Change in fair value of deferred and contingent consideration liabilities | - | - | - | - | - | - | - | - | - | - | 7 | -21 | 29 | 92 |
|---|
| Change in fair value of interest rate swap | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 | -0 |
|---|
| Vertuis acquisition | - | - | - | - | - | - | - | - | - | - | - | - | 10 | - |
|---|
| Adrestia acquisition | - | - | - | - | - | - | - | - | - | - | - | - | 76 | - |
|---|
| Accounts receivable | 0 | -1 | - | - | - | - | - | 6 | 14 | -3 | 8 | 6 | 12 | 13 |
|---|
| Inventory | - | - | - | - | - | - | - | 7 | 21 | 21 | 17 | 2 | 14 | 17 |
|---|
| Prepaid expenses and other current assets | 0 | 0 | 2 | 3 | 1 | -0 | 3 | 6 | 9 | 3 | 6 | -3 | -2 | 14 |
|---|
| Other assets | - | - | - | - | - | - | - | - | 16 | 6 | 24 | 25 | 20 | -8 |
|---|
| Increase (Decrease) in Accounts Payable | 1 | 5 | -1 | 3 | -2 | 3 | 4 | 4 | -5 | 30 | -8 | 50 | 15 | 45 |
|---|
| Other liabilities | - | - | - | - | - | - | - | - | - | - | - | - | - | -12 |
|---|
| Net cash used in operating activities | -30 | -31 | - | - | - | - | -160 | -258 | -251 | -219 | -363 | -400 | -536 | -684 |
|---|
| Purchase of fixed assets | 1 | 0 | 1 | 5 | 3 | 4 | 3 | 13 | 42 | 6 | 7 | 10 | 13 | 22 |
|---|
| Purchase of marketable securities | - | - | - | - | - | - | - | - | - | - | 50 | 100 | 589 | 1,600 |
|---|
| Cash acquired in asset acquisition | - | - | - | - | - | - | - | - | - | - | - | - | 3 | - |
|---|
| Maturities of marketable securities | - | - | - | - | - | - | - | - | - | - | - | - | - | 1,016 |
|---|
| Net cash used in investing activities | 34 | 62 | - | - | - | - | -3 | -15 | -42 | -7 | -64 | -35 | -224 | -583 |
|---|
| Proceeds from Stock Options Exercised | - | 0 | 2 | 1 | 5 | 1 | 3 | 9 | 20 | 26 | 22 | 20 | 18 | 113 |
|---|
| Proceeds from Issuance of Common Stock | 0 | 26 | 67 | 109 | 223 | - | 378 | - | 261 | 246 | 270 | 292 | 152 | 1,084 |
|---|
| Proceeds from issuance of Term Loans | - | - | - | - | - | - | - | - | - | - | - | 350 | - | 150 |
|---|
| Proceeds From Royalty Financing | - | - | - | - | - | - | - | - | - | - | - | 150 | - | - |
|---|
| Payment of debt issuance costs | - | 0 | 0 | 0 | 0 | 0 | - | 14 | - | - | 16 | 18 | 1 | 4 |
|---|
| Payments of finance lease principal | - | - | - | - | - | - | - | - | - | 1 | - | - | 1 | 3 |
|---|
| Net cash provided by financing activities | -0 | 45 | - | - | - | - | 381 | 387 | 285 | 271 | 613 | 793 | 168 | 1,341 |
|---|
| Effect of exchange rates on cash and cash equivalents | - | - | - | - | - | - | - | - | - | - | -1 | -1 | -0 | -1 |
|---|
| Net increase (decrease) in cash and cash equivalents | - | - | - | - | - | - | - | - | -8 | 45 | 184 | 357 | -592 | 73 |
|---|
| Cash paid for interest | - | - | - | - | - | - | - | 6 | 8 | 9 | 11 | 10 | 36 | 41 |
|---|
| Income Taxes Paid, Net | - | - | 1 | 9 | 3 | -0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 2 |
|---|