| Dec 31, 2011 | Dec 31, 2012 | Dec 31, 2013 | Dec 31, 2014 | Dec 31, 2015 | Dec 31, 2016 | Dec 31, 2017 | Dec 31, 2018 | Dec 31, 2019 | Dec 31, 2020 | Dec 31, 2021 | Dec 31, 2022 | Dec 31, 2023 |
---|
Net loss | -60 | -41 | -56 | -79 | -118 | -176 | -193 | -324 | -254 | -294 | -435 | -482 | -750 |
---|
Depreciation | - | - | - | - | - | - | - | 4 | 5 | 9 | 9 | 5 | 6 |
---|
Amortization of intangible assets | - | - | - | - | - | - | - | 1 | 5 | 5 | 5 | 5 | 5 |
---|
Stock-based compensation expense | 2 | 3 | 9 | 11 | 16 | 18 | 18 | 26 | 27 | 36 | 46 | 58 | 75 |
---|
Loss on extinguishment of debt | - | - | - | - | - | - | - | -2 | - | - | -18 | - | - |
---|
Amortization of debt issuance costs | - | - | - | - | - | 0 | 0 | 1 | 1 | 1 | - | 4 | 7 |
---|
Accretion Expense | - | - | 0 | 0 | 0 | 0 | 1 | 0 | - | - | - | - | - |
---|
Paid-in-Kind Interest | - | - | - | - | - | - | - | - | - | - | - | 4 | 23 |
---|
Other Noncash Expense | - | - | - | - | - | - | - | - | - | - | - | 4 | 19 |
---|
Finance lease amortization expense | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 2 | 3 |
---|
Accretion of discount on marketable securities, net | - | - | - | - | - | - | - | - | - | - | - | - | 9 |
---|
Noncash Operating Lease Expense | - | - | - | - | - | - | - | - | 10 | 6 | 13 | 12 | 9 |
---|
Finance lease amortization expense | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 2 | 3 |
---|
Change in fair value of deferred and contingent consideration liabilities | - | - | - | - | - | - | - | - | - | - | 7 | -21 | 29 |
---|
Noncash Operating Lease Expense | - | - | - | - | - | - | - | - | 10 | 6 | 13 | 12 | 9 |
---|
Change in fair value of interest rate swap | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 |
---|
Change in fair value of deferred and contingent consideration liabilities | - | - | - | - | - | - | - | - | - | - | 7 | -21 | 29 |
---|
Accounts receivable | 0 | -1 | - | - | - | - | - | 6 | 14 | -3 | 8 | 6 | 12 |
---|
Inventory | - | - | - | - | - | - | - | 7 | 21 | 21 | 17 | 2 | 14 |
---|
Prepaid expenses and other current assets | 0 | 0 | 2 | 3 | 1 | -0 | 3 | 6 | 9 | 3 | 6 | -3 | -2 |
---|
Other assets | - | - | - | - | - | - | - | - | 16 | 6 | 24 | 25 | 20 |
---|
Increase (Decrease) in Accounts Payable | 1 | 5 | -1 | 3 | -2 | 3 | 4 | 4 | -5 | 30 | -8 | 50 | 15 |
---|
Other liabilities | - | - | - | - | - | - | - | - | - | - | 5 | -13 | -11 |
---|
Net cash used in operating activities | -30 | -31 | - | - | - | - | -160 | -258 | -251 | -219 | -363 | -400 | -536 |
---|
Change in fair value of interest rate swap | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 |
---|
Vertuis Bio, Inc. | - | - | - | - | - | - | - | - | - | - | - | - | 10 |
---|
Adrestia Therapeutics Ltd | - | - | - | - | - | - | - | - | - | - | - | - | 76 |
---|
Vertuis Bio, Inc. | - | - | - | - | - | - | - | - | - | - | - | - | 10 |
---|
Adrestia Therapeutics Ltd | - | - | - | - | - | - | - | - | - | - | - | - | 76 |
---|
Accounts receivable | 0 | -1 | - | - | - | - | - | 6 | 14 | -3 | 8 | 6 | 12 |
---|
Inventory | - | - | - | - | - | - | - | 7 | 21 | 21 | 17 | 2 | 14 |
---|
Prepaid expenses and other current assets | 0 | 0 | 2 | 3 | 1 | -0 | 3 | 6 | 9 | 3 | 6 | -3 | -2 |
---|
Other assets | - | - | - | - | - | - | - | - | 16 | 6 | 24 | 25 | 20 |
---|
Increase (Decrease) in Accounts Payable | 1 | 5 | -1 | 3 | -2 | 3 | 4 | 4 | -5 | 30 | -8 | 50 | 15 |
---|
Other liabilities | - | - | - | - | - | - | - | - | - | - | 5 | -13 | -11 |
---|
Net cash used in operating activities | -30 | -31 | - | - | - | - | -160 | -258 | -251 | -219 | -363 | -400 | -536 |
---|
Net loss | -60 | -41 | -56 | -79 | -118 | -176 | -193 | -324 | -254 | -294 | -435 | -482 | -750 |
---|
Depreciation | - | - | - | - | - | - | - | 4 | 5 | 9 | 9 | 5 | 6 |
---|
Amortization of intangible assets | - | - | - | - | - | - | - | 1 | 5 | 5 | 5 | 5 | 5 |
---|
Stock-based compensation expense | 2 | 3 | 9 | 11 | 16 | 18 | 18 | 26 | 27 | 36 | 46 | 58 | 75 |
---|
Loss on extinguishment of debt | - | - | - | - | - | - | - | -2 | - | - | -18 | - | - |
---|
Amortization of debt issuance costs | - | - | - | - | - | 0 | 0 | 1 | 1 | 1 | - | 4 | 7 |
---|
Accretion Expense | - | - | 0 | 0 | 0 | 0 | 1 | 0 | - | - | - | - | - |
---|
Paid-in-Kind Interest | - | - | - | - | - | - | - | - | - | - | - | 4 | 23 |
---|
Other Noncash Expense | - | - | - | - | - | - | - | - | - | - | - | 4 | 19 |
---|
Finance lease amortization expense | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 2 | 3 |
---|
Accretion of discount on marketable securities, net | - | - | - | - | - | - | - | - | - | - | - | - | 9 |
---|
Noncash Operating Lease Expense | - | - | - | - | - | - | - | - | 10 | 6 | 13 | 12 | 9 |
---|
Finance lease amortization expense | - | - | - | - | - | - | - | - | 0 | 1 | 1 | 2 | 3 |
---|
Change in fair value of deferred and contingent consideration liabilities | - | - | - | - | - | - | - | - | - | - | 7 | -21 | 29 |
---|
Noncash Operating Lease Expense | - | - | - | - | - | - | - | - | 10 | 6 | 13 | 12 | 9 |
---|
Change in fair value of interest rate swap | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 |
---|
Change in fair value of deferred and contingent consideration liabilities | - | - | - | - | - | - | - | - | - | - | 7 | -21 | 29 |
---|
Accounts receivable | 0 | -1 | - | - | - | - | - | 6 | 14 | -3 | 8 | 6 | 12 |
---|
Inventory | - | - | - | - | - | - | - | 7 | 21 | 21 | 17 | 2 | 14 |
---|
Prepaid expenses and other current assets | 0 | 0 | 2 | 3 | 1 | -0 | 3 | 6 | 9 | 3 | 6 | -3 | -2 |
---|
Other assets | - | - | - | - | - | - | - | - | 16 | 6 | 24 | 25 | 20 |
---|
Increase (Decrease) in Accounts Payable | 1 | 5 | -1 | 3 | -2 | 3 | 4 | 4 | -5 | 30 | -8 | 50 | 15 |
---|
Other liabilities | - | - | - | - | - | - | - | - | - | - | 5 | -13 | -11 |
---|
Net cash used in operating activities | -30 | -31 | - | - | - | - | -160 | -258 | -251 | -219 | -363 | -400 | -536 |
---|
Change in fair value of interest rate swap | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 |
---|
Vertuis Bio, Inc. | - | - | - | - | - | - | - | - | - | - | - | - | 10 |
---|
Adrestia Therapeutics Ltd | - | - | - | - | - | - | - | - | - | - | - | - | 76 |
---|
Vertuis Bio, Inc. | - | - | - | - | - | - | - | - | - | - | - | - | 10 |
---|
Adrestia Therapeutics Ltd | - | - | - | - | - | - | - | - | - | - | - | - | 76 |
---|
Accounts receivable | 0 | -1 | - | - | - | - | - | 6 | 14 | -3 | 8 | 6 | 12 |
---|
Inventory | - | - | - | - | - | - | - | 7 | 21 | 21 | 17 | 2 | 14 |
---|
Prepaid expenses and other current assets | 0 | 0 | 2 | 3 | 1 | -0 | 3 | 6 | 9 | 3 | 6 | -3 | -2 |
---|
Other assets | - | - | - | - | - | - | - | - | 16 | 6 | 24 | 25 | 20 |
---|
Increase (Decrease) in Accounts Payable | 1 | 5 | -1 | 3 | -2 | 3 | 4 | 4 | -5 | 30 | -8 | 50 | 15 |
---|
Other liabilities | - | - | - | - | - | - | - | - | - | - | 5 | -13 | -11 |
---|
Net cash used in operating activities | -30 | -31 | - | - | - | - | -160 | -258 | -251 | -219 | -363 | -400 | -536 |
---|
Purchase of fixed assets | 1 | 0 | 1 | 5 | 3 | 4 | 3 | 13 | 42 | 6 | 7 | 10 | 13 |
---|
Purchase of marketable securities | - | - | - | - | - | - | - | - | - | - | 50 | 100 | 589 |
---|
Maturities of marketable securities | - | - | - | - | - | - | - | - | - | - | - | 75 | 375 |
---|
Cash acquired in asset acquisition | - | - | - | - | - | - | - | - | - | - | - | - | 3 |
---|
Cash paid for Business Acquisition, net | - | - | - | - | - | - | - | - | - | - | 7 | - | - |
---|
Maturities of marketable securities | - | - | - | - | - | - | - | - | - | - | - | 75 | 375 |
---|
PARI milestone upon regulatory approvals | - | - | - | - | - | - | - | 2 | - | 1 | - | - | - |
---|
Cash paid for Business Acquisition, net | - | - | - | - | - | - | - | - | - | - | 7 | - | - |
---|
Net cash used in investing activities | 34 | 62 | - | - | - | - | -3 | -15 | -42 | -7 | -64 | -35 | -224 |
---|
Proceeds from Stock Options Exercised | - | 0 | 2 | 1 | 5 | 1 | 3 | 9 | 20 | 26 | 22 | 20 | 18 |
---|
Proceeds from Issuance of Common Stock | 0 | 26 | 67 | 109 | 223 | - | 378 | - | 261 | 246 | 270 | 292 | 152 |
---|
Payment on extinguishment of 1.75% convertible senior notes due 2025 | - | - | - | - | - | - | - | 3 | - | - | 13 | - | - |
---|
Payment of principal of 1.75% convertible senior notes due 2025 | - | - | - | - | - | - | - | - | - | - | 225 | - | - |
---|
Proceeds from Convertible Debt | - | - | - | - | - | - | - | 450 | - | - | 575 | - | - |
---|
Proceeds from issuance of Term Loan | - | - | - | - | - | - | - | - | - | - | - | 350 | - |
---|
Proceeds From Royalty Financing | - | - | - | - | - | - | - | - | - | - | - | 150 | - |
---|
Payment of debt issuance costs | - | 0 | 0 | 0 | 0 | 0 | - | 14 | - | - | 16 | 18 | 1 |
---|
Other financing activities | - | - | - | - | - | - | - | - | - | - | -1 | -1 | - |
---|
Payments of finance lease principal | - | - | - | - | - | - | - | - | - | 1 | - | - | 1 |
---|
Net cash provided by financing activities | -0 | 45 | - | - | - | - | 381 | 387 | 285 | 271 | 613 | 793 | 168 |
---|
Effect of exchange rates on cash and cash equivalents | - | - | - | - | - | - | - | - | - | - | -1 | -1 | -0 |
---|
Net (decrease) increase in cash and cash equivalents | - | - | - | - | - | - | - | - | -8 | 45 | 184 | 357 | -592 |
---|
Cash paid for interest | - | - | - | - | - | - | - | 6 | 8 | 9 | 11 | 10 | 36 |
---|
Income Taxes Paid, Net | - | - | 1 | 9 | 3 | -0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 |
---|
Purchase of fixed assets | 1 | 0 | 1 | 5 | 3 | 4 | 3 | 13 | 42 | 6 | 7 | 10 | 13 |
---|
Purchase of marketable securities | - | - | - | - | - | - | - | - | - | - | 50 | 100 | 589 |
---|
Maturities of marketable securities | - | - | - | - | - | - | - | - | - | - | - | 75 | 375 |
---|
Cash acquired in asset acquisition | - | - | - | - | - | - | - | - | - | - | - | - | 3 |
---|
Cash paid for Business Acquisition, net | - | - | - | - | - | - | - | - | - | - | 7 | - | - |
---|
Maturities of marketable securities | - | - | - | - | - | - | - | - | - | - | - | 75 | 375 |
---|
PARI milestone upon regulatory approvals | - | - | - | - | - | - | - | 2 | - | 1 | - | - | - |
---|
Cash paid for Business Acquisition, net | - | - | - | - | - | - | - | - | - | - | 7 | - | - |
---|
Net cash used in investing activities | 34 | 62 | - | - | - | - | -3 | -15 | -42 | -7 | -64 | -35 | -224 |
---|
Proceeds from Stock Options Exercised | - | 0 | 2 | 1 | 5 | 1 | 3 | 9 | 20 | 26 | 22 | 20 | 18 |
---|
Proceeds from Issuance of Common Stock | 0 | 26 | 67 | 109 | 223 | - | 378 | - | 261 | 246 | 270 | 292 | 152 |
---|
Payment on extinguishment of 1.75% convertible senior notes due 2025 | - | - | - | - | - | - | - | 3 | - | - | 13 | - | - |
---|
Payment of principal of 1.75% convertible senior notes due 2025 | - | - | - | - | - | - | - | - | - | - | 225 | - | - |
---|
Proceeds from Convertible Debt | - | - | - | - | - | - | - | 450 | - | - | 575 | - | - |
---|
Proceeds from issuance of Term Loan | - | - | - | - | - | - | - | - | - | - | - | 350 | - |
---|
Proceeds From Royalty Financing | - | - | - | - | - | - | - | - | - | - | - | 150 | - |
---|
Payment of debt issuance costs | - | 0 | 0 | 0 | 0 | 0 | - | 14 | - | - | 16 | 18 | 1 |
---|
Other financing activities | - | - | - | - | - | - | - | - | - | - | -1 | -1 | - |
---|
Payments of finance lease principal | - | - | - | - | - | - | - | - | - | 1 | - | - | 1 |
---|
Net cash provided by financing activities | -0 | 45 | - | - | - | - | 381 | 387 | 285 | 271 | 613 | 793 | 168 |
---|
Effect of exchange rates on cash and cash equivalents | - | - | - | - | - | - | - | - | - | - | -1 | -1 | -0 |
---|
Net (decrease) increase in cash and cash equivalents | - | - | - | - | - | - | - | - | -8 | 45 | 184 | 357 | -592 |
---|
Cash paid for interest | - | - | - | - | - | - | - | 6 | 8 | 9 | 11 | 10 | 36 |
---|
Income Taxes Paid, Net | - | - | 1 | 9 | 3 | -0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 |
---|