| Dec 31,
2017 | Dec 31,
2018 | Dec 31,
2019 | Dec 31,
2020 | Dec 31,
2021 | Dec 31,
2022 | Dec 31,
2023 | Dec 31,
2024 |
|---|
| Net loss | -6,251,730 | -7,480,815 | -7,359,364 | -9,474,175 | -29,605,266 | -40,370,040 | -63,779,116 | -111,779,105 |
|---|
| Depreciation | 104,704 | 223,037 | 338,996 | 385,591 | 303,235 | 210,918 | 142,772 | 129,947 |
|---|
| Stock-based compensation | 874,386 | 1 | 1 | 2 | 3 | 5 | 5 | 7 |
|---|
| Amortization of debt issuance costs and discount | - | - | - | - | 267,821 | 395,757 | 241,752 | 1 |
|---|
| Payment-in-Kind interest | - | - | - | - | - | 455,074 | 2 | 1 |
|---|
| Non-cash operating lease, net | - | - | - | - | - | - | - | -434 |
|---|
| Change in accrued interest income | - | - | - | - | - | - | - | -150,421 |
|---|
| Other current assets | - | - | - | - | - | - | 3 | -775,981 |
|---|
| Accounts payable | -262,507 | 25,432 | 45,617 | 52,971 | 1 | 1 | 2 | 4 |
|---|
| Accrued expenses | 392,315 | -44,349 | 111,403 | 190,293 | 28,280 | 3 | 5 | 13 |
|---|
| Net cash used for operating activities | -4,947,982 | -6,076,269 | -5,998,711 | -7,145,689 | -20,311,940 | -36,008,171 | -53,812,253 | -83,466,743 |
|---|
| Proceeds from maturities of investments | - | - | - | - | - | - | 310 | 642 |
|---|
| Purchases of investments | 29 | 3 | - | - | - | 144 | 315 | 705 |
|---|
| Purchases of property and equipment | 239,848 | 629,608 | 380,201 | -89,371 | 81,898 | 158,768 | 97,644 | 249,878 |
|---|
| Net cash used for investing activities | -28,976,983 | 19 | 9 | -89,371 | -81,398 | -144,031,794 | -5,008,207 | -63,069,283 |
|---|
| Proceeds from exercise of common stock warrants | 2,052 | 183,759 | 3,752 | - | 18,762 | - | 22,505 | 15 |
|---|
| Proceeds from exercise of employee stock options | - | - | 174,958 | - | 63,420 | 152,412 | 388,522 | 769,571 |
|---|
| Proceeds from employee stock purchases | - | - | - | - | - | - | 202,845 | 275,601 |
|---|
| Proceeds from follow-on offering, net of underwriting discounts and offering costs | - | - | - | - | - | - | - | 56 |
|---|
| Proceeds from note payable, net of debt issuance costs and discount of $2,437,644 | - | - | - | - | 14 | 20 | - | 59 |
|---|
| Proceeds from an ATM offering, net of issuance costs | - | - | - | - | - | - | - | 7 |
|---|
| Proceeds from pre-funded warrants, net of offering costs | - | - | - | - | - | - | 50 | - |
|---|
| Payments for secondary registration statement costs | - | - | - | - | - | - | 45,805 | 227,405 |
|---|
| Payments for debt issuance costs | 40,961 | - | - | - | - | - | 2,716 | - |
|---|
| Payments for finance leases | - | - | - | - | - | 5,850 | 2,449 | - |
|---|
| Net cash provided by financing activities | 31 | 236,697 | 259,305 | 137,969 | 93 | 120 | 65 | 138 |
|---|
| Net change in cash and cash equivalents | - | 13 | - | - | 73 | -59,714,824 | 6 | -8,147,951 |
|---|
| Interest paid | - | - | - | - | 694,528 | 1 | 3 | 8 |
|---|
| Deferred financing costs and offering and registration statement costs included in accounts payable | - | - | - | - | - | 51,020 | 56,414 | 42,028 |
|---|
| Property and equipment included in accounts payable | - | - | - | - | - | - | 13,615 | 1,417 |
|---|
| Common stock warrants issued with the note payable transaction | - | - | - | - | - | - | - | 1 |
|---|